Final Program dated June 8, 2018


Sunday, June 17, 2018

6:00 – 9:00 PM

Session I         Opening Ceremony at Botanical Gardens, Wade Oval, University Circle


Introduction: Alvin H. Schmaier, M.D., University Hospitals Cleveland Medical Center, Case Western Reserve University

Welcome Address: Daniel I Simon, M.D., President, University Hospitals Cleveland Medical Center


Dinner Buffet will be Provided


Monday, June 18, 2018

Tinkham Veale University Center


7:00 – 8:00 a.m.               Registration and Continental Breakfast

8:00 – 8:15 a.m.               Opening and Introduction


Session II       Chair: Allen P. Kaplan, Medical College of South Carolina

8:15-8:45 a.m.               Structural Biology of Factor XII                              

Jonas Emsley, Nottingham University, England      


8:45-9:15 a.m.               Polyphosphates in Health and Disease        

Thomas Renne, Uni Med Center Hamburg-Eppendorf, Germany


9:15-9:45 a.m.               Platelet Polyphosphates & Factor XII

Nicola Mutch, University of Aberdeen, Aberdeen, United Kingdom


9:45-10:15 a.m.               Coffee Break & Visit Exhibits


Session III      Chair: Thomas Renne, Univ Med Center Hamburg-Eppendorf, Germany

10:15-10:45 a.m.               Single Chain Factor XIIa      

David Gailani, Vanderbilt University, Nashville


11:15-11:45 a.m.               Polyphosphates and Complement Activation

Edward Conway, University of British Columbia, Vancouver, Canada


11:45 a.m.-12:00 p.m.               Influence of Polyphosphates Chain Length on Individual Reactions of the Contact Pathway

Yuqi Wang, University of Michigan, Ann Arbor


12:00-12:15 p.m.               The Surface of Activated Platelets Enhances the Activity of FXIa Towards FIX

Stephanie E. Reitsma, Oregon Health & Science Univ, Portland, OR


12:15-1:00 p.m.               Lunch & Visit Exhibits


1:00-2:00 p.m.               Day 1 Poster Viewing & Visit Exhibits


Session IV      Chair: Keith McCrae, Cleveland Clinic

2:00-2:30 p.m.               Surface Activation of Contact System -Thrombin Generation and Platelet Activation

 Owen McCarty, Oregon Health and Science University


2:30-3:00 p.m.               Neutrophil Factor XII in Inflammation and Thrombosis

Evi Stavrou, Case Western Reserve University


3:00-3:30 p.m.               Kininogen: A Key Player in Innate Immunity

Yi Wu, Temple University


3:30-3:45 p.m.                Coffee Break & Visit Exhibits


Session V        Chair: David Gailani, Vanderbilt University

3:45-4:15 p.m.                Kallikrein Inhibition in Diabetic Macular Edema

Edward Feener, KalVista, Inc. Boston MA


4:15-4:45 p.m.                Targeting Factor XIIa: Potential for Safe Anticoagulation and More . . .                          

Con Panousis, CSL Behring, Melbourne, Australia


4:45-5:15 p.m.                Landelumab, Characterization and Use

Jon Kenniston, Shire, Lexington, MA


5:15-5:30 p.m.               KLK6-PAR1 Signaling Drives Psoriasiform Manifestation in Skin and Bone

Nicole Ward, Dermatology, Case Western Reserve University


5:30-5:45 p.m.                  Human Factor XII Mutation W268R Causes Cryopyrin-Associated Periodic Syndrome Through Intracellular Processing

Steven de Maat, University Medical Center Utrecht, Utecht, Netherlands


5:45 p.m.                                  Adjournment Day One


Networking Sessions at Cleveland Indians & Chicago White Sox Game

Progressive Field, Cleveland, OH

6:30 p.m. - Meet Buses for the Cleveland Indians vs. Chicago White Sox Game - Dinner Purchased at Game


Tuesday, June 19, 2018


7:30-8:30 a.m.                        Continental Breakfast and Visit Exhibits


Session VI      Chair: Jonas Emsley, Nottingham University, England

8:30-9:00 a.m.                 Structural Basis for C1 Inhibitor Inhibition by Polysaccharides

Navraj Pannu, Leiden University, Netherlands                    


9:00-9:30 a.m.                Making a Better C1 Inhibitor

Coen Mass, University Medical Center Utrecht                  


9:30-9:45 a.m.                Comparison of RNAi-mediated Suppression of Factor XII, Plasma Kallikrein, and High Molecular Weight Kininogen in a Mouse Vascular Permeability Model

Jingxuan Liu, Alnylam Pharmaceuticals, Cambridge MA


9:45-10:00 a.m.                Whole Exome Sequencing of Individuals with Hereditary Angioedema of Unknown Molecular Basis Focused on Vascular Permeability Related Genes

Renan Martin, Johns Hopkins Univ. and UNIFESP of Sao Paulo


10:00-10:30 a.m.               Coffee Break & Visit Exhibits


Session VII    Chair: Allen P. Kaplan, Medical College of South Carolina

10:30-11:00 a.m.               Hereditary Angioedema – The Architype Disease of the Kallikrein/Kinin System          

 Andrea Zanichelli, University of Milan, Milan


11:00-11:30 a.m.              Complexity of Treatment Choices for Hereditary Angioedema

Bruce Zuraw, University of California at San Diego, San Diego


11:30 a.m.-12:00 p.m.        Angioedema and Kinins

Joao B. Pesquero, Universidade Federal de Sao Paulo, Brazil


12:00-12:15 p.m.                Mechanism of Hereditary Angioedema with Normal C1-INH and Mutations in the Factor XII Gene

Ivan Ivanov, Vanderbilt University


12:15-1:00 p.m.                 Lunch & Visit Exhibits


1:00-2:00 p.m.                 Day 2 Poster Viewing& Visit Exhibits


Session VIII   Chair: Joao Pesquero, Universidade Federal de Sao Paulo, Brazil

2:00-2:30 p.m.               Novel Transgenic Rat Models that Overexpress Endothelial Cell B1 and B2 Receptors

Michael Bader, Max Delbruck Ctr for Molecular Medicine, Berlin


2:30-3:00 p.m.               Role of B1 Receptor in Inflammation Associated with Vasculitis

Diana Karpman, Lund University, Lund, Sweden


3:00-3:30 p.m.                Role of BK/B2R: Regulation of Collecting Duct Renin

Minolfa Prieto, Tulane University, New Orleans


3:15-3:30 p.m.               Regulation of Differentially Coupled G-Protein-Coupled Receptors Through Non-Visual G Protein-Coupled Receptor Kinases

Alexander Faussner, Institute for Cardiovascular Prevention, Ludwig-Maximillians University, Munich


3:30-3:45 p.m.               Coffee Break and Visit Exhibits


Session IX      Chair: Sadashiva S. Karnik, Cleveland Clinic

3:45-4:15 p.m.               Angiotensin-(1-7) and Mas in Vascular Biology

Robson A. S. Santos, Federal University of Minas Gerais, Belo Horizonte, Brazil


4:15-4:45 p.m.               Angiotensin 2 Receptor in Vascular Biology and Hypertension

Robert M. Carey, University of Virginia, Charlottesville, VA


4:45-5:00 p.m.              Deficiency of the Bradykinin B2 Receptor Decreases Atherosclerotic Lesion Formation in     ApoE Knockout Mice

 Andreas Langer, Molecular Pharmacology, ETH Zurich


5:00-5:15 p.m.                Tonin Overexpression in Mice Diminishes Sympathetic Autonomic Modulation and             Increases  Angiotensin Type 1 Receptor Response

Zaira Palomino Jara, Cleveland Clinic


5:15 p.m.                  Adjournment Day Two


Networking Session at the Cleveland Rock and Roll Hall of Fame

6:30-6:45 p.m.         Meet Buses for Closing Ceremony at the Cleveland Rock and Roll Hall of Fame

Buffet Dinner will be Provided


Wednesday, June 20, 2018


7:30-8:30 a.m.                 Continental Breakfast and Visit Exhibits


Session X       Chair: Marvin T, Nieman, Case Western Reserve University

8:30-9:00 a.m.                Biased Agonism of RAS Receptors

Louis Luttrell, Medical College of South Carolina, Charleston, SC


9:00-9:30 a.m.               Pathologic Effects of AT1-B2 Receptors Heteromers in Transgenic Models

Ursula Quitterer, ETH Zurich and University of Zurich


9:30-9:45 a.m.               Kinin B2 Receptor Mutants Found in Hereditary Angioedema Patients Display Biased Agonism

Rafael Filippelli-Silva, UNIFESP, Sao Paulo


9:45-10:00 a.m.              Transgenic Rats Overexpressing Kinin B2 Receptor in Vascular Endothelium Develop Spontaneous Angioedema

Camila Lopes Veronez, MDC, Berlin and UNIFESP of Sao Paulo


10:00-10:30 a.m.               Coffee Break and Visit Exhibits


Session XI     Chair: Jackson Wright, Case Western Reserve University

10:30-11:00 a.m.              Neprilysin Inhibitors and Bradykinin

Duncan J. Campbell, University of Melbourne, Melbourne


11:00-11:30 a.m.               Biochemistry of Neprilysin in Cardiorenal Disease

John C. Burnett, Mayo Clinic, Rochester


11:30-11:45 a.m.                RKIP Induces Heart Failure by Promoting Angiotensin II AT1Receptor Hyperactivity

 Stefan Wolf, Molecular Pharmacology, ETH Zurich


11:45-12:00 a.m.                Renal Kallikrein 1 Activity and Bradykinin Levels are Reduced in Mice with Prorenin                                                    Receptor (PRR) Deficiency in the Collecting Duct

Bruna Visniauskas, Tulane University


12:00-1:00 p.m.                 Lunch & Visit Exhibits


1:00-1:30 p.m.                   Award Ceremony


1:30-2:00 p.m.                   Business Meeting for All (Planning for Next Meeting)


Session XII    Chair: Michael Bader, Max Delbruck Ctr for Molecular Med Berlin

2:00-2:30 p.m.                 Bradykinin Receptor Antagonism in ACE-Induced Angioedema

Nancy J Brown, Vanderbilt University, Nashville


2:30-3:00 p.m.               Kallikrein, Kin and ACE (kininase II) in Ischemic and Diabetic Disease – New Therapies

Francois Alhenc-Gelas, Paris Descartes Medical School, Pierre et Marie Curie University, Paris


3:00-3:15 p.m.               Microvascular Ona Chip: A Dynamic Model for Studying Endothelial Response to               Permeability Mediators

Maddalena Alessandra Wu, U of Milan, Italy


3:15-3:30 p.m.                The Modulation of Kinin Receptors by Physical Exercise in Acute Kidney Injury Induced by LPS

Talita GR Hungaro, UNIFESP Sao Paulo


3:30-3:45 p.m.               Coffee Break and Visit Exhibits


Session XIII   Chair: James Kazura, Case Western Reserve Univ, Cleveland OH

3:45-4:15 p.m.                Trypanosoma Cruzi and Bradykinin Receptors

Julio Scharfstein, Universidade Federal de Rio de Janeiro, Rio de Janeiro


4:15-4:45 p.m.              Bradykinin and Mas Receptors in Invasion by P. falciparum

Ana A.S. Pinheiro, Universidade Federal de Rio de Janeiro, Rio de Janeiro


4:45-5:00 p.m.                Activation of the Kallikrein Kinin System Has Detrimental Effects in a Mouse Model of         Peritonitis Induced by Bacteroides Fragilis

Matheus Palazzo, Universidade Federal do Rio de Janeiro


5:00-5:15 p.m.               Carboxypeptidase N Deficiency: Identification of Families Carrying Variants in the CPN1     Gene

 Christian Drouet, University of Grenoble, France


5:15-5:30 p.m.                Bradykinin Oxidative Stress, and Mitochondrial Function in Patients on Hemodialysis

Jorge L. Gamboa, Vanderbilt University


5:30 p.m.                      Conference Adjourns